AHFS Monograph Vitamin E 8820 (revised Sept 2005)

Short Description
Vitamin E is a fat-soluble vitamin and an antioxidant. … The NAS has established an EAR and RDA for vitamin E for adults based …

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Content
Vitamin E VITAMIN E 88:20
AHFS DRUG INFORMATION?2004 1
Vitamin E
Vitamin E is a fat-soluble vitamin and an antioxidant.
Uses
? Dietary Requirements
The National Academy of Sciences (NAS) has issued a comprehensive set
of Recommended Dietary Allowances (RDAs) as reference values for dietary
nutrient intakes since 1941. In 1997, the NAS Food and Nutrition Board (part
of the Institute of Medicine [IOM]) announced that they would begin issuing
revised nutrient recommendations that would replace RDAs with Dietary Reference
Intakes (DRIs). DRIs are reference values that can be used for planning
and assessing diets for healthy populations and for many other purposes and
that encompass the Estimated Average Requirement (EAR), the Recommended
Dietary Allowance (RDA), the Adequate Intake (AI), and the Tolerable Upper
Intake Level (UL).
The NAS has established an EAR and RDA for vitamin E for adults based
on induced vitamin E deficiency in humans and the correlation between hydrogen
peroxide-induced erythrocyte lysis and plasma ?-tocopherol concentrations.
The EAR and RDA for children and adolescents 1-18 years of age were
estimated using metabolic formulas, which were extrapolated from adult values
based…