Dietary Intake of Vitamin A and Osteoporosis

Short Description
vitamin A(retinol) is associated with decreased bone miner- … tors did not affect the impact of vitamin A on risk for either …

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Content
Study Overview
Objective. To investigate whether excessive dietary intake of
vitamin A(retinol) is associated with decreased bone mineral
density and increased risk for hip fracture.
Design. Population-based, cross-sectional study and a nested
case-control study.
Setting and participants. The setting was two counties in central
Sweden. Atotal of 175 women aged 28 to 74 years of age
were randomly selected for the cross-sectional study [1]. For
the case-control study, 247 women who had a first hip fracture
within 2 to 64 months after enrollment and 873 age-matched
controls were selected from women aged 40 to 76 years participating
in the Swedish Mammography Cohort [2].
Main outcome measures. Vitamin A intake was estimated
using dietary records and a food-frequency questionnaire.
Dual-energy x-ray absorptiometry was used to measure
bone mineral density at the lumbar spine, the total body, and
three regions of the proximal femur. Hip fracture was confirmed
by reviewing hospital discharge records. Patients also
completed questionnaires about risk factors for osteoporosis
(eg, smoking); diabetes diagnosis and treatment; use of cortisone,
hormone replacement therapy, or oral contraceptives;
menopausal status; and physical activity.
Main results. After adjusting for potentially confounding…