THE SPARING ACTION OF FAT ON VITAMIN B In our studies on the …

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interaction of fat with the vitamin B in the alimentary canal. … spares vitamin B when inadequate amounts of this vitamin are. given intraperitoneally. …

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THE SPARING ACTION OF FAT ON VITAMIN B
IV. IS IT NECESSARY FOR FAT TO INTERACT WITH VITAMIN B
IN THE ALIMENTARY CANAL TO EXERT ITS SPARING EFFECT?*
BY HERBERT M. EVANS AND SAMUEL LEPKOVSKY
(From the Institute of Experimental Biology, University of California,
Berkeley)
(Received for publication, September 28, 1932)
In our studies on the influence of fat upon the vitamin B (1)
requirements of the rat, the question arose as to whether the
beneficial effects of the fat could in any way be the result of the
interaction of fat with the vitamin B in the alimentary canal.
The answer to this question was sought in the parenteral administration
of either vitamin B or the fat or both. To date,
attempts to administer parenterally fats in sufficient quantities
to exert a definite sparing action has met with failure. However,
it is possible to administer vitamin B parenterally, and we desire
in this note to present evidence which shows that fat in the diet
spares vitamin B when inadequate amounts of this vitamin are
given intraperitoneally. Litter mate sisters were reared on either
a fat-free diet or one which contained 25 per cent cottonseed oil….