QUANTITATIVE EXPERIMENTS ON THE OCCUR RENCE OF VITAMIN B IN ORGANS …

Short Description
Before the differentiation of vitamin B into its two factors, … soluble vitamin B in the diet, induced normal growth but that …

Website: jn.nutrition.org | Filesize: 664kb

Content
QUANTITATIVE EXPERIMENTS ON THE OCCUR
RENCE OF VITAMIN B IN ORGANS
JESSIE B. BBODIE AND FLOEENCE L. MACLEOD
Department of Chemistry, Columbia University, New fork City
TWO PIQURES
(Beceived for publication March 23, 1935)
Before the differentiation of vitamin B into its two factors,
B(B!) and G(B2), investigations had been made to show the
antineuritic and the growth-promoting effects of different
organs of the body. Cooper (’12) showed that smaller
amounts of sheep ’s brain and ox-heart were necessary to pro
tect against polyneuritis than of beef muscle. Later Cooper
(’14) concentrated, from cardiac muscle, a substance which
would cure polyneuritis and Funk ( ‘12) concentrated a similar
substance from ox-brain. Eddy (’17) improved the growth
of children and of rats suffering from marasmus by giving
them an extract of sheep’s pancreas.
Osborne and Mendel (’18) showed that 19 per cent dried
pig’s cardiac muscle, 22 per cent kidney, 32 per cent brain or
10 per cent liver, as the sole source of protein and watersoluble
vitamin B in the diet, induced normal growth but that
5 per cent liver failed to do so. Drummond ( ‘18)…