Leptomeningeal Metastasis from Malignant Pleural Mesothelioma

Short Description
Malignant mesothelioma of the right pleura in a 61-year-old … At autopsy, mesothelioma with infiltration of the lower lobe of. the right lung was evident. …

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Content
Leptomeningeal Metastasis from Malignant
Pleural Mesothelioma
Boris D. Petrovic, Dusko B. Kozic, Robert R. Semnic, Mladen Prvulovic, Dragana Djilas-Ivanovic,
R. Nuri Sener, and Istvan Klem
Summary: Leptomeningeal metastasis from malignant mesothelioma
is very rare; to our knowledge, only one imaging
report exists in the literature. We present the case of widespread
leptomeningeal lesions secondary to a malignant
mesothelioma in a 61-year-old woman.
CNS involvement due to metastatic mesothelioma
is very rare. The metastatic intracranial lesion may
present as a solitary mass or as leptomeningeal infiltration
(1-7). Leptomeningeal metastasis is extremely
rare, and to our knowledge, only one report of the
MR imaging findings of this condition exists in the
literature (1). Herein, we believe we report the imaging
findings in the second such reported case of this
condition.
Case Report
Malignant mesothelioma of the right pleura in a 61-year-old
woman was confirmed by pleurolysis and biopsy (Fig 1A and
B). Although she responded well to chemotherapy, 1 year later
she was admitted to the hospital because of vomiting, for which
she received symptomatic therapy. A year thereafter, she was
admitted again with confusion and ataxia, at which time T2-
weighted images…