Triplet Chemotherapy for Malignant Pericardial Mesothelioma A …

Short Description
(A) A cytological examination of the pericardial effusion indicating the typical findings of malignant mesothelioma. (B) Immunohistochemistry using …

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Content
Case Report
Triplet Chemotherapy for Malignant Pericardial
Mesothelioma: A Case Report
Riichiroh Maruyama1, Maki Sakai1, Tomomi Nakamura1, Ryuichi Suemitsu1, Tatsuro Okamoto1,
Hiroshi Wataya1, Kenichi Nishiyama2, Toshiaki Kamei3 and Yukito Ichinose1
1Department of Thoracic Oncology, 2Pathology, Kyushu Cancer Center, Fukuoka and 3Division of Pathology,
Yamaguchi Prefectural Grand Medical Center, Yamaguchi, Japan
Received October 17, 2005; accepted December 27, 2005
Malignant pericardial mesothelioma (MPM) is a relatively rare neoplasm in Japan, and no
standard treatment regimens have been established for this disease. A 47-year-old woman with
MPM presenting with cardiac tamponade was treated using four cycles of chemotherapy consisting
of cisplatin (CDDP) 40 mg/m2, gemcitabine (GEM) 800 mg/m2 and vinorelbine (VNR)
20 mg/m2 on days 1 and 8 every 4 weeks after pericardial drainage alone. The diagnosis of
MPM was confirmed by an immunohistochemical procedure using either positive or negative
markers of malignant mesothelioma in addition to conventional cytological examinations using
pericardial effusion. The patient experienced no severe non-hematological or hematological
toxicities except for grade 3 neutropenia. The patient…