Treatment of Primary Peritoneal Mesothelioma by Continuous …

Short Description
the MTD for treatment of their peritoneal mesothelioma. The treatment toxicities are ….. in the treatment of peritoneal mesothelioma is that it does …

Website: www.annalssurgicaloncology.org | Filesize: 139kb

Content
Treatment of Primary Peritoneal Mesothelioma by
Continuous Hyperthermic Peritoneal Perfusion (CHPP)
Bernard J. Park, MD, H. Richard Alexander, MD, Steven K. Libutti, MD, Peter Wu, MD,
Dan Royalty, BA, Karen C. Kranda, RN, and David L. Bartlett, MD
Background: Primary peritoneal mesothelioma is a locally aggressive disease that is difficult to
treat or even palliate. Continuous hyperthermic peritoneal perfusion (CHPP) with cisplatin (CDDP)
allows uniform, high regional delivery of chemotherapeutics and hyperthermia to the peritoneal
surface for the treatment of peritoneal tumors. This article summarizes the results of 18 patients with
peritoneal mesothelioma treated with CHPP.
Methods: From June 1993 through April 1998, 18 patients with primary peritoneal mesothelioma
(13 male, 5 female; median age, 51 years) underwent surgical exploration and tumor debulking
followed by a 90-minute CHPP with CDDP and hyperthermia as part of three consecutive phase I
trials conducted at the National Cancer Institute. Seventeen of 18 patients had malignant peritoneal
mesothelioma, 13 with associated ascites. One patient had a symptomatic, multiply recurrent,
benign, cystic peritoneal mesothelioma. Three patients who had a recurrence after a prolonged
progression-free interval (6 months) after CHPP underwent re-treatment. CHPP parameters
included median cisplatin…