Melatonin Administration Alters Semen Quality in Healthy Men

Short Description
cebo given orally at 1700 hours in 8 healthy men. Semen quality ….. ratio (C) in 8 healthy men during 6 months of melatonin-. placebo administration. …

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Journal of Andrology, Vol. 23, No. 4, July/August 2002
Copyright q American Society of Andrology
Melatonin Administration Alters Semen Quality in Healthy
Men
RAFAEL LUBOSHITZKY,* ZILLA SHEN-ORR,?RACHEL NAVE,?SCHAHAR LAVI,?AND PERETZ LAVIE?
From the *Department of Endocrinology, Haemek Medical Center, Afula, Israel; the ?Department of Endocrinology,
Rambam Medical Center, Haifa, Israel; and the ?Sleep Laboratory, B. Rappaport Faculty of Medicine
Technion-Israel Institute of Technology, Haifa, Israel.
ABSTRACT: The role of melatonin in the regulation of reproduction
in humans is unknown. We conducted a 6-month, double-blind,
crossover study of a daily treatment dose of 3 mg melatonin or placebo
given orally at 1700 hours in 8 healthy men. Semen quality
(concentration, motility, and morphology), serum and seminal plasma
17-b-estradiol (E2), testosterone, melatonin, and serum gonadotropin
levels were determined every 3 months throughout the study.
In 6 men, there was no change in semen quality or in serum and
seminal plasma hormone levels during the study period. In 2 men,
during the melatonin treatment period, sperm concentration decreased
to 3 3 106/mL and 12 3 106/mL, and motility declined to
32% and 30%….