Cognitive Effects of Short-Term Manipulation of Serum Sex Steroids …

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We examined the effects of sex steroids on cognitive function-. ing by exogenously manipulating circulating T levels in a. group of healthy young men. …

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Cognitive Effects of Short-Term Manipulation of Serum
Sex Steroids in Healthy Young Men
M. M. CHERRIER, B. D. ANAWALT, K. L. HERBST, J. K. AMORY, S. CRAFT, A. M. MATSUMOTO,
AND W. J. BREMNER
Departments of Psychiatry and Behavioral Sciences (M.M.C., S.C.) and Medicine (B.D.A., K.L.H., J.K.A., W.J.B.), University
of Washington School of Medicine, Seattle, Washington 98195; and Geriatric Research (M.M.C.), Education and Clinical
Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108
We examined the effects of sex steroids on cognitive functioning
by exogenously manipulating circulating T levels in a
group of healthy young men. Thirty-two men were randomized
to receive 8 wk of treatment including: 1) im T enanthate
100 mg/wk plus daily oral placebo (T); 2) im placebo/wk plus
125 g daily oral levonorgestrel (LNG); 3) im T enanthate 100
mg/wk plus 125g daily oral LNG (T LNG); 4) im placebo/wk
plus daily oral placebo. Cognitive functions were assessed at
baseline and twice during treatment. Serum T and E2 levels
were significantly increased in the T…